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After his wife's death, the eccentric, famed doctor and veterinarian of Victorian England, John Dolittle (Robert Downey, Jr.) isolates himself away behind the high walls of Dolittle Manor with his animals for company. When Queen Victoria (Jessie Buckley) falls ill, a reluctant Dolittle is forced to go on an epic adventure to a mythical island in search of a cure, regaining his wit and courage as he crosses old adversaries and encounters wondrous creatures.