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Host Farron Dozier, SFC Retired A Sickle Cell Trait Advocate who experienced what they call a rare case of sickle cell exertion with rhabdo has been interviewing the sickle cell community on this platform for 10yrs... This episode is a conversation that I feel has labled without hearing how people who actually live with these two separate genes each passed by one from each parent. Sickle Cell Trait and C-Trait. They both have their own inherited conversation. 50% chance for Trait and 25% chance with Disease and 25% chance with no genes passed. This how the describe SC Disease:
HbSC
People who have this form of SCD inherit a sickle cell gene (“S”) from one parent and from the other parent a gene for an abnormal hemoglobin called “C”. Hemoglobin is a protein that allows red blood cells to carry oxygen to all parts of the body. This is usually a milder form of SCD. Here is what they say about the other genes:
HbSS
People who have this form of SCD inherit two sickle cell genes (“S”), one from each parent. This is commonly called sickle cell anemia and is usually the most severe form of the disease.
HbS beta thalassemia
People who have this form of SCD inherit one sickle cell gene (“S”) from one parent and one gene for beta thalassemia, another type of anemia, from the other parent. There are two types of beta thalassemia: “0” and “+”. Those with HbS beta 0-thalassemia usually have a severe form of SCD. People with HbS beta +-thalassemia tend to have a milder form of SCD. Oh and don't forget: HbSD, HbSE, and HbSO and the main in all Sickle Cell Trait aka AS aka SCT. https://www.cdc.gov/ncbddd/sicklecell/facts.html